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KMID : 1143820050010010025
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Anxiety and Mood
2005 Volume.1 No. 1 p.25 ~ p.30
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[GABA_A]-Benzodiazepine Receptor and Anxiety Disorder
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Lee Sang-Yeol
Park Min-Cheol
Kang He-Ja
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Abstract
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In the 40 years since the first benzodiazepine was brought into clinical use there has been a substantial growth in understanding the molecular basis of action of these drugs and the role of their receptors in anxiety disorders. Benzodiazepine receptors are present throughout the brain with the highest concentration in cortex, and it potentiate and prolong the synaptic action of the inhibitory neurotransmitter GABA. Central benzodiazepine receptors and [GABA_A] receptors are part of the same macromolecular complex. Abnormalities of these [GABA_A]-benzodiazepine receptors as a result of drug challenge tests and neuroimaging studies may underlie some anxiety disorders. The role of [GABA_A]-benzodiazepine receptors in the action of benzodiazepine and as a factor in anxiety disorder, in both animal and humans including knock-out and knock in technique, may lead to new anxiolytics that have potentially significant therapeutic gains without unwanted side effects.
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KEYWORD
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GABA_A, Benzodiazepine, Receptor, Anxiety disorder
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